Deal of the Day ? Dell Inspiron 15R-2nd Gen 2.4GHz 2nd Gen Intel Core i5 Laptop w/6GB RAM

Dell Home now offers the 15.6-inch Dell Inspiron 15R-2nd Gen ?Sandy Bridge? Core i5-2430M 2.4GHz Dual-core Laptop with Switchable lids starting at $818.99 – $259 off = $549.99 with FREE shipping. That’s the lowest price for a Core i5 configuration on Inspiron 15R-2nd gen model currently. Base configuration also includes 640GB Hard Drive, 6GB RAM, [...]

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BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancer

Public release date: 4-Dec-2011
[ | E-mail | Share ]

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen

Study published online today in Nature Genetics

December 4th, 2011, Cambridge, MA and Shenzhen, China BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may contribute to ccRCC by activation of the hypoxia regulatory network, providing new clues to trace the key molecular mechanisms and pathways that underlie the tumorigenesis and progression of ccRCC.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of kidney cancer, with 102,000 deaths worldwide each year. It is characterized by high metastatic potential and poor prognosis. Up to 40% of patients have disease recurrence after nephrectomy. In this study, the research team specifically looked at alterations in ubiquitin-mediated proteolysis pathway and studied its potential impacts linked to ccRCC tumorigenesis. The UMPP has been reported to be associated with many diseases including cancer and plays a critical role in the protein metabolism as a major pathway for protein degradation in cells.

"Adding to the previous research effort of transitional cell carcinoma in bladder cancer published in Nature Genetics earlier this year, we and our partners continued our study of strongly aggressive ccRCC tumors to identify the mutated genes associated with the process of tumorigenesis," said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "The new discoveries in this study led us to a remarkable step in our understanding of the genetic landscape of ccRCCs and toward potential treatment against this aggressive tumor."

To gain a deep insight into the genetic basis of ccRCC, researchers analyzed ten primary tumors with matched morphologically normal renal tissues utilizing the whole exome sequencing approach on BGI's sequencing platform. The mutation prevalence was estimated by screen of ~1,100 genes with somatic mutations or that have been causally implicated in cancers in 88 additional ccRCCs for prevalence screen.

There were 23 significantly mutated genes identified in the 98 ccRCCs, including the five well-known renal cancer genes such as VHL and TP53, and genes involved in chromatin modification such as PBRM1, JARID1C and SETD2. "We have identified 12 genes which were previously unknown to be involved in ccRCC, including two tumor suppressor genes, BAP1 and TSC1. Integration of previous studies and our findings suggest that some of the genes may play important roles in ccRCC genesis," said Guo.

In addition to the attempt to identify all mutated genes associated with ccRCC, researchers also focused on specific genes, pathways and mechanisms that potentially play a key role in ccRCC tumorgenesis and warrant exploration as potential targets for treatments. One of the targets was mutations in VHL gene that were commonly suggested to be involved in ccRCC genesis in many previous genetic studies with reported prevalence ranging between 50% and 80%. Interestingly, researchers have found a much lower prevalence of 27% in this study. VHL promoter hypermethylation was only found in 6% of the tumors relative to their matched normal samples, also suggesting a lower prevalence of epigenetic VHL alternation, according to the researchers.

Although the alteration of VHL gene is widely known for its association with kidney cancer, researchers also revealed the frequent mutation of UMPP linked to ccRCC in this study and have sequenced all 135 genes in UMPP in the prevalence screen. A significantly high mutation frequency of UMPP was found in the 98 carcinoma samples. The pathway analysis suggested that alternation of UMPP could potentially play an important role in ccRCC tumorigenesis, and it may contribute by activating the hypoxia regulatory network.

"This study has enhanced our knowledge and laid an important foundation for future research of ccRCC. The new discovery on the potential contribution of UMPP to ccRCC justifies more comprehensive investigation of this pathway, including proteomics research of the protein network to fully elucidate its role in ccRCC genesis," said Professor Jun Wang, Executive Director of BGI.

###

About BGI

BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.

BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 170 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, have sequenced the human Gut Metagenome, and a significant proportion of the genomes for the1000 Genomes Project. For more information about BGI, please visit www.genomics.cn or www.bgiamericas.com.

Contact Information:

Guangwu Guo, Ph.D.
Group Leader of Cancer Genome Analysis,
BGI
guogw@genomics.cn
www.genomics.cn

Joyce Peng, Ph.D.
Marketing Director
BGI Americas
626-222-5584
joyce.peng@bgiamericas.com
www.bgiamericas.com

Bicheng Yang, Ph.D.
Public Communication Officer
BGI
+86-755-82639701
yangbicheng@genomics.cn
www.genomics.cn

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 4-Dec-2011
[ | E-mail | Share ]

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen

Study published online today in Nature Genetics

December 4th, 2011, Cambridge, MA and Shenzhen, China BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may contribute to ccRCC by activation of the hypoxia regulatory network, providing new clues to trace the key molecular mechanisms and pathways that underlie the tumorigenesis and progression of ccRCC.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of kidney cancer, with 102,000 deaths worldwide each year. It is characterized by high metastatic potential and poor prognosis. Up to 40% of patients have disease recurrence after nephrectomy. In this study, the research team specifically looked at alterations in ubiquitin-mediated proteolysis pathway and studied its potential impacts linked to ccRCC tumorigenesis. The UMPP has been reported to be associated with many diseases including cancer and plays a critical role in the protein metabolism as a major pathway for protein degradation in cells.

"Adding to the previous research effort of transitional cell carcinoma in bladder cancer published in Nature Genetics earlier this year, we and our partners continued our study of strongly aggressive ccRCC tumors to identify the mutated genes associated with the process of tumorigenesis," said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "The new discoveries in this study led us to a remarkable step in our understanding of the genetic landscape of ccRCCs and toward potential treatment against this aggressive tumor."

To gain a deep insight into the genetic basis of ccRCC, researchers analyzed ten primary tumors with matched morphologically normal renal tissues utilizing the whole exome sequencing approach on BGI's sequencing platform. The mutation prevalence was estimated by screen of ~1,100 genes with somatic mutations or that have been causally implicated in cancers in 88 additional ccRCCs for prevalence screen.

There were 23 significantly mutated genes identified in the 98 ccRCCs, including the five well-known renal cancer genes such as VHL and TP53, and genes involved in chromatin modification such as PBRM1, JARID1C and SETD2. "We have identified 12 genes which were previously unknown to be involved in ccRCC, including two tumor suppressor genes, BAP1 and TSC1. Integration of previous studies and our findings suggest that some of the genes may play important roles in ccRCC genesis," said Guo.

In addition to the attempt to identify all mutated genes associated with ccRCC, researchers also focused on specific genes, pathways and mechanisms that potentially play a key role in ccRCC tumorgenesis and warrant exploration as potential targets for treatments. One of the targets was mutations in VHL gene that were commonly suggested to be involved in ccRCC genesis in many previous genetic studies with reported prevalence ranging between 50% and 80%. Interestingly, researchers have found a much lower prevalence of 27% in this study. VHL promoter hypermethylation was only found in 6% of the tumors relative to their matched normal samples, also suggesting a lower prevalence of epigenetic VHL alternation, according to the researchers.

Although the alteration of VHL gene is widely known for its association with kidney cancer, researchers also revealed the frequent mutation of UMPP linked to ccRCC in this study and have sequenced all 135 genes in UMPP in the prevalence screen. A significantly high mutation frequency of UMPP was found in the 98 carcinoma samples. The pathway analysis suggested that alternation of UMPP could potentially play an important role in ccRCC tumorigenesis, and it may contribute by activating the hypoxia regulatory network.

"This study has enhanced our knowledge and laid an important foundation for future research of ccRCC. The new discovery on the potential contribution of UMPP to ccRCC justifies more comprehensive investigation of this pathway, including proteomics research of the protein network to fully elucidate its role in ccRCC genesis," said Professor Jun Wang, Executive Director of BGI.

###

About BGI

BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.

BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 170 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, have sequenced the human Gut Metagenome, and a significant proportion of the genomes for the1000 Genomes Project. For more information about BGI, please visit www.genomics.cn or www.bgiamericas.com.

Contact Information:

Guangwu Guo, Ph.D.
Group Leader of Cancer Genome Analysis,
BGI
guogw@genomics.cn
www.genomics.cn

Joyce Peng, Ph.D.
Marketing Director
BGI Americas
626-222-5584
joyce.peng@bgiamericas.com
www.bgiamericas.com

Bicheng Yang, Ph.D.
Public Communication Officer
BGI
+86-755-82639701
yangbicheng@genomics.cn
www.genomics.cn

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2011-12/bs-brs120211.php

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Video: Hedge Funds Regain Losses

Tory Gayeski, Skybridge Capital sr. portfolio manager, says hedge funds focused on corporate capital structure have been hurt by risk-on, risk-off action. "You want to be focused on strategies that have very attractive cash flows," he says.

Related Links:

Business & financial news headlines from msnbc.com

Source: http://video.msnbc.msn.com/cnbc/45550501/

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West Palm Beach Luxury Homes Deliver Superb Value For Real Estate Within South Florida Today

It is true that more and more people are turning to South Florida in the hopes of being able to find the most opulent real estate opportunities that are available in the region. One such location that has proven to be a city that has genuinely been able to grant people with utmost satisfaction in their luxury homes is West Palm Beach in Palm Beach County.

The city of West Palm Beach is located along the coast of the Atlantic Ocean which means that people can look forward to an astounding collection of superb waterfront luxury homes that are sure to delight potential buyers.

Many find the warm atmosphere is definitely something that adds to the charm of the city, but the fact that the city offers luxury real estate opportunities that hold the most value on today?s market is truly something that attracts high profile individuals to find their dream home in the area.

With many upscale neighborhoods to choose from, potential buyers who are hoping to find the most outstanding luxury deals on the market will certainly feel at ease with the fabulous quality of West Palm Beach luxury homes that never fail to impress even the most meticulous of property experts. In fact, many find it hard to describe how stunning each one is because they all have their own unique qualities that make them all so ideal for many reasons.

Naturally, people will want to have home spaces that are fully functional. Being able to offer people the absolute luxury of being able to have one of the many West Palm Beach luxury homes that are built upon spacious lots of land which can be utilized to cater to the needs of today?s luxury real estate buyers since there really are many of them who are coming to South Florida for those exact reasons.

It would be no surprise to find out that there have been many who have come to call the city of West Palm Beach their own home. From entertainment figures to political icons and many more, the unparalleled beauty of living in the dynamic city definitely speaks out to those who know how to find the best value in South Florida, especially when it comes to luxury real estate because West Beach Palm luxury homes are truly on a level of their own which is what makes them one of the best options that people can consider on the market today.

Joan Vonnegut
West Palm Beach Luxury Homes

Source: http://www.turks.us/article.php?story=20111203112649174

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Video: Japanese Robot Climbs Up And Down Ladders By Itself

We're getting closer and closer to the Robocalypse: Osaka-based industrial equipment maker Muscle Corporation and a few other Japanese companies have developed a humanoid that can climb up (and down) ladders all by itself. Considering how hard it still is to create robots that can walk smoothly, this is quite an accomplishment. The so-called "Dream Robo" was actually showcased last year during the Shanghai Expo. It stands 1.4m high, weighs about 30kg and moves with the help of five motors that are built into its body.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Ep0dMZYs6yM/

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Investing in a Political Malaise | Gold News

Why investors are pushed towards low-yielding Treasuries...

FOLLOWING a long and drawn-out political debacle on both sides of the Atlantic, the developed economies remain embedded in a crisis that the political systems are unable, or unwilling, to resolve, writes Julian Phillips at GoldForecaster.?

The leaders of the developed world are capable, competent men who have what it takes to surmount the debt crises that are consuming confidence day by day. So why don't they?

Fitch Ratings gave the United States until 2013 to come up with a "credible plan" to tackle its ballooning budget deficit or risk a downgrade of the country's coveted, AAA rating. The ratings agency revised the outlook from stable to negative on the US credit rating after a special congressional committee failed last week to agree on at least $1.2 trillion in deficit-reduction measures.?

The committee failure made it unlikely that any meaningful deficit plan will be adopted next year, increasing the fiscal burden on the next administration that will be elected in late 2012, Fitch said. Fitch said the chance of a downgrade is "slightly greater than 50%".

With unemployment still hovering around 9%, it is likely that Federal Reserve policymakers will consider further monetary stimulus in an effort to give growth some support and to lower the risk of another US recession. While it may appear to be capable of stimulating growth, it will decrease the value of the US Dollar both internally and internationally.?

The German bond auction, last week, and Italy's bond auction were poorly received with Italian 2-year bond yields rising to 7.8% from 3.45%. The International Monetary Fund is not in talks with Italy to provide financial assistance. It does not have the resources to do so either. This week, Italy had to pay nearly 8% for its loans.

Belgium's credit rating has been cut by Standard and Poor's to AA from AA+. The Belgian state's capacity to prevent an increase in general government debt, which we consider to be already at high levels, is being constrained by rapid private sector deleveraging both in Belgium and among many of Belgium's key trading partners?

Standard & Poor's could change the outlook for France's triple-A rating to negative within the next 10 days.?

France's ratings outlook is currently stable with S&P, but there have been rumors for months of a possible downgrade by one or more of the ratings agencies.

Moody's said it could downgrade the subordinated debt of 87 banks across 15 European Union nations on concerns that governments would be too cash-strapped to bail out holders of riskier bank debt in times of stress. Most of the ratings to be reviewed were in Spain, Italy, Austria, and France.?

The review could lead to an average potential downgrade of subordinated debt by two notches, and junior subordinated debt and Tier 3 debt by one notch. Moody's believes that systemic support for subordinated debt in Europe is becoming ever more unpredictable due to a combination of anticipated changes in policy and financial constraints.?

Nations affected by review were listed as Austria (nine banks), Belgium (three), Cyprus (two), Finland (three), France (seven), Italy (17), Luxembourg (three), Netherlands (six), Norway (five), Poland (one), Portugal (two), Slovenia (two), Spain (21), Sweden (four) and Switzerland (two). Moody's also warned that the risk to ratings on subordinated debt could extend outside the borders of the European Union.

Banks and ratings agencies are sounding their loudest warnings ?the Euro area risks unraveling unless its guardians quickly intensify efforts to beat the two-year sovereign debt crisis. European finance chiefs prepare to meet this week, yet again, but hopes are barely discernible. Moody's said this week the "rapid escalation" of the crisis threatens all of the region's sovereign ratings. Europe has accumulated too much public debt. It is in deep disagreement about the way forward. Its banks are short of capital and have difficulties funding. It has lost most of its internal growth dynamic. And bond investors have lost trust, draining away in droves and causing a liquidity crisis with the ECB wishing to stick to its purity and Germany sticking to its guns.

So far, all we have are deepening sovereign and bank funding problems, governments being replaced, growth a lost dynamic, and despair the general currency. So it isn't too difficult to see a final EU crisis moment approaching in which markets cause asset prices to collapse, and there isn't sufficient public support to keep things afloat (never mind reform and regain market trust). And that moment, by all omens, may be neigh. So 2012 could, for all in the developed world, be another 2008 or 1998, as an EU disruption.?

With the mental capacities, the power and control, why aren't politicians resolving financial crisis? This is an easy question to ask, but the answer is far from simple. Take the concept of democracy. This is a structure espoused as the answer to all ills, pushed forward by the developed world, in particular. What is democracy in the context of today's crises??

It's an institution that requires all people over a certain age (with very few exceptions) to state their support for a very few, selected individuals usually belonging to one of around three political parties to vote for one of this small number of choices that they feel will carry out their wishes as defined by the party's manifesto. Parties decide their manifesto ahead of elections that take place around five years at a time.?

Outside those elections, individuals have little or no choice in politics. Therefore politicians gear their actions to achieving the most popularity just ahead of those dates. This allows unpopular actions to be taken early in the term of elected politicians and for popularity to be garnered close to the elections. So the extent of the individual choice is very limited and occasional.

But something has gone very wrong with this system in the EU and the USA. currently. The result of elections in so many developed world nations has left nations with such a fine balance of power on the political front that governments are not able to govern effectively. In the US the Republicans and Democrats have managed to stalemate each other to the extent that they can get little governing done on the budget deficit. So strong are party politics, that the interests of the nation they govern have been sidelined. Party politics have transcended national interests. The same is true in the Eurozone, where government over-borrowing has been allowed against the European Union to which they swore allegiance. Even in the midst of the worst crisis the E.U. has faced, national politicians are failing to rise over national and party politics to save the Eurozone from individual or collective insolvency.

As one EU politician so aptly put it, "We know what to do, but the problem is getting re-elected after we've done it".?

So now we wait in this limbo of indecision, with little prospect of change coming. When will they act? Again democratic politics has a specific influence over their actions. When a politician acts to resolve a problem that requires unpopular measures, he rarely stays in power, victim of the unpopularity of voting support. When voters feel the pain of those problems, their attitudes change.?

Now their only hope is political action to remove that pain. Now unpopular measures are acceptable to the electorate, desperate to feel relief. In fact if these work, then the politician that imposes such measures is hailed a hero in his land and is likely to be re-elected. We're now waiting for the pain to strike.?

You can be sure it will strike before the next US Presidential elections. The skill of the President is to make sure the oppositions takes the blame. The skill of the oppositions is to make sure the President takes the blame. Both hope the electorates are gullible enough to support them and not to blame the system that rules them and to push for a change of system.

Contrast this with a system that believes it knows its people's wishes better than they do themselves, such as China. There the rule of government is almost complete, allowing them to manage the economy and monetary system without oppositions and with only muted criticism. A look at the economy of the two tells its own tale. Nevertheless citizens in China place their trust is savings and in particular gold, not the government systems.

With political considerations set far above financial ones, only the explosion of confidence in national money will swing political considerations behind financial ones. This seems and easy answer, but it isn't. The ailments of the financial system extend to its very structure: the banking system. The longer it takes to resolve the financial crises, the worse it gets. Once the decay in confidence has passed a certain point, it's impossible to fix.?

Then there needs to be a restructuring of the system. The worse the level of confidence, the more radical the re-structuring needs to be. The more re-structuring there needs to be, the stronger the hold of government over its nation needs to be. That means there will need to be an overwhelming dominance of one party or another so as to avoid the current developed world impasses. To date, the performance of developed world political parties falls short of inspiring such support.

So what does an investor do?

In the developed world he can hop from one investment to another in the hope he has found some special formula that will save his wealth. Once this fails he may turn to another. For instance he may turn to US Treasuries as the ultimate of liquid markets or cash (at the short end). But Treasury prices at all end of the Yield Curve have never been so high, so capital appreciation is not expected. Yield increases would mean falling prices and losses if one bought now. But this is the tree trunk of the fictional currency system, so there's nowhere else to turn.

Buying Gold?...

Source: http://goldnews.bullionvault.com/political_investing_120120112

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Italy mulls closing Tehran embassy: foreign minister (Reuters)

ROME (Reuters) ? Italy is considering closing its embassy in Tehran and will summon the Iranian ambassador to ask for guarantees for the safety of the country's diplomats after the assault on the British embassy, Foreign Minister Giulio Terzi said on Wednesday.

"We're seeking firm guarantees," from the Iranians, Terzi told reporters after testimony in parliament. "We're reflecting rapidly on the presence of our ambassador and our diplomatic personnel (in Tehran)," he said.

He also said Italy would decide together with its European allies and the United States about a possible oil embargo against Iran.

(Reporting By Roberto Landucci, writing by Steve Scherer)

Source: http://us.rd.yahoo.com/dailynews/rss/iran/*http%3A//news.yahoo.com/s/nm/20111130/wl_nm/us_italy_iran_embassy

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